A review on direct synthesis of dimethoxymethane

Polyoxymethylene dimethyl ethers are recognized as the prospective diesel additive to decrease the pollutant emission from the light-duty vehicles, which can be polymerize form the monomer of dimethoxymethane (DMM). The industrial synthesis of DMM is mainly involved two-step process: methanol is oxidized to form the formaldehyde in fixed bed reactor and then reacted with the generated formaldehyde through acetalization in continuous stirred-tank reactor. Due to huge energy consumption, this typical synthesis route of DMM needs to be upgraded and more green routes should be determined. In this review, four state-of-the-art one-step direct synthetic routes, including two upgrading routes (methanol direct oxidation and direct dehydrogenation) and two green routes (methanol diethyl ether direct oxidation and carbon oxides direct hydrogenation), have been summarized and compared. Combination with the reaction mechanism and catalytic performance on the different catalysts, the challenges and opportunities for every synthetic route are proposed. The relationships between catalyst structure and property in different synthesis strategy are also investigated and then the suggestions of the design of catalyst are given about future research directions that efforts should be made in. Hopefully, this review can bridge the gap between newly developed catalysts and synthesis technology to realize their commercial applications in the near future.     

Numerical Evaluation of Grouting Scenarios for Reducing Water Inflows from Major Faults in Underground Excavations

Mine Water and the Environment - Water inflows through fracture networks are a major economic and safety issue in underground mines. Although pre-grouting of pilot holes during mine development...     

一种使用多跳事实的端到端知识库实体描述生成方法

自动化实体描述生成有助于进一步提升知识图谱的应用价值,而流畅度高是实体描述文本的重要质量指标之一。该文提出使用知识库上多跳的事实来进行实体描述生成,从而贴近人工编撰的实体描述的行文风格,提升实体描述的流畅度。该文使用编码器—解码器框架,提出了一个端到端的神经网络模型,可以编码多跳的事实,并在解码器中使用关注机制对多跳事实进行表示。该文的实验结果表明,与基线模型相比,引入多跳事实后模型的BLEU-2和ROUGE-L等自动化指标分别提升约8.9个百分点和7.3个百分点。     

放射性气载流出物取样代表性分析

为获取核设施放射性气载流出物单点连续监测取样位置,提出基于随机轨道模型(DRW)的气-固多相湍流耦合方法求解代表性取样区域。借助k-epsilon湍流模型模拟连续相,并引入离散颗粒模型(DPM)模拟离散相,建立基于DRW模型的排风管道内流道气-固多相湍流耦合计算模型,计算了核设施气载流出物在管道内流道流场分布规律,分析了内流道流体气旋角、气流速度、示踪气体浓度、气溶胶粒子浓度与管道高度间的关联关系。分析结果表明,随着截面高度的增加,气旋角、气流速度变异系数(COV)、示踪气体浓度COV及示踪气体浓度最大值与平均值的偏差逐渐降低并趋于稳定,气溶胶粒子浓度COV在截面6与截面8满足取样代表性要求;基于计算流体动力学方法可快速地确定出代表性取样位置,为气载流出物单点取样现场试验提供了理论参考依据。     

Combating Biofilm Associated Infection In Vivo: Integration of Quorum Sensing Inhibition and Photodynamic Treatment based on Multidrug Delivered Hollow Carbon Nitride Sphere

Recently, quorum sensing (QS) inhibitors (QSIs) have been combined with antibiotics to enhance antibiofilm efficacy in vitro and in vivo. However, targeting QS signals alone is not enough to prevent bacterial infections. Drug resistance and recurrence of biofilms makes it difficult to eradicate. Herein, photodynamic therapy (PDT) is selected to unite QSIs and antibiotics. A synergistically antibiofilm system, which combines QSIs, antibiotics, and PDT based on hollow carbon nitride spheres (HCNSs) is envisaged. First, HCNS provides the multidrug delivering ability, enabling QSIs and antibiotics to be released in sequence. Subsequently, multistage releases sensitize bacteria effectively, potentiating the chemotherapeutic effects of the antibiotics. Finally, the integration of QSIs and PDT not only minimizes the possibility of drug resistance, but also overcomes the problem of limited mass and extension of PDT. Even after 48 h of incubation, the bacterial biofilm is obviously inhibited. And its biofilm disperse efficiency exceeds 48% (compared with QSI‐potentiated chemotherapy group) and 40% (compared with PDT group). Besides, the inhibition of the QS system influences phenotypes related to virulence factor production and surface hydrophobicity, which weaken biofilm invasion and formation. Eventually, this system is applied to disperse bacterial biofilm in vivo. Overall, PDT and QS modulation are devoted to eradicate drug resistance and recurrence of the biofilm.     

蜂窝梁的稳定性能研究进展

对蜂窝梁破坏模式的研究表明，失稳是其结构性能失效的重要破坏模式。为此，在回顾蜂窝梁结构特性研究的基础上，总结归纳了蜂窝梁失稳的3种主要模式：整体弯扭失稳、梁墩屈曲、畸变屈曲。结合国内外近30多年来对蜂窝梁稳定性的试验研究成果，对影响蜂窝梁稳定性的主要因素进行分析。采用蒙特卡洛法得到纯弯简支蜂窝梁弯扭失稳临界荷载的概率分布和影响因子的敏感度。将部分具有代表性的试验成果与欧洲规范EN 1993-1-1计算结果进行对比，根据中国规范GB 50068—2001《建筑结构可靠度设计统一标准》提供的抗力分项系数，计算了不同荷载组合下蜂窝梁整体弯扭失稳临界荷载的可靠度指标，为国内规范的制订提供依据。最后，总结了当前蜂窝梁稳定性研究中存在的不足，指明了进一步研究的方向。     

基于种群划分与变异策略的粒子群优化算法

粒子群算法因其形式比较简洁，参数设置灵活，操作简便易行，并且能够快速收敛，从而引起广泛关注。但是传统的粒子群算法也有缺陷：收敛速度慢以及容易陷入局部最优等。针对这些问题，本文借鉴小生境的方法，在进化初始阶段，对种群进行划分，将初始种群分为子种群，对不同的子种群进行不同的变异策略；在进化过程中，针对不同的子种群，设置不同的惯性权重因子ω，用来增强全局搜索能力与局部搜索能力。实验结果表明，本文提出的算法较传统的粒子群算法具有较快的收敛性以及找寻的全局最优解更接近真实解集，收敛精度比较高。     

基于三维纳米阵列结构的表面增强拉曼技术研究及其在痕量铀酰离子探测中的应用

表面增强拉曼散射(SERS)是一种新型痕量表征技术，其灵敏度高、样品用量少、特征谱易辨识，尤其适用于铀酰离子等危化品的探测。在过去十几年里, 纳米材料和纳米技术在新兴技术和SERS的应用方面获得了长足发展，将先进的纳米制造技术引入了SERS领域。本文总结了利用光刻、原子层沉积等技术，开发了一系列高质量的三维阵列纳米材料作为SERS基底，并应用于痕量铀酰离子的检测。其中，以Al₂O₃、HfO₂等惰性氧化物包裹修饰的银纳米棒三维阵列作为基底，灵敏度高，稳定性好，根据不同特征的拉曼振动频谱，可识别多个不同种态的铀酰离子，检出限低至nmol/L，具有潜在的实际应用价值。     

A Method of Applying Flight Data to Evaluate Landing Operation Performance

Abstract

Pilots’ operation has an important effect on flight safety and performance, particularly in the final landing stage when pilots need to deal with complicated operations. This study aims to determine the potential value of flight data and develop a method of evaluating a pilot’s performance during landing phase based on flight quick access recorder (QAR) data from the perspective of risk assessment. First, a Landing Operation Performance Evaluation Model was developed based on risk evaluation principles. Three landing parameters, which are touchdown distance, touchdown vertical acceleration and touchdown pitch angle, were selected as indicators to evaluate the pilots’ landing operation performance in this model. Second, the flight landing operation performance evaluation system (FLOPES) was set up based on the evaluation model. Test results showed that FLOPES can accomplish all calculation flow of operation performance evaluation. Finally, it concluded that this method is a more accurate and effective way for evaluating the landing operation performance of a flight. It could be as a practical tool for airlines to manage landing risk quantitatively and to provide a more practical support for improving training and design in aviation.Practitioner summary: This study aims to determine the potential value of flight data and to develop a method of evaluating pilot’s landing operation performance from the risk evaluation perspective. Test results showed that this method is effective and could be as a practical tool for airlines to manage landing risk and improve training.Abbreviations:QAR: Quick Access Recorder; FLOPES: Flight Landing Operation Performance Evaluation System; ICAO: International Civil Aviation Organization; IATA: International Air Transport Association; SMS: Safety Management System; CAAC: Civil Aviation Administration of China; FOQA: Flight Operations Quality Assurance; VBA: Visual Basic for Applications